Aims

Our goal is to understand the mechanisms of neurological diseases characterised by genetic disorders of synaptic function, and apply this to identify therapeutic targets.

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We address the following questions:

  • How do combinations of inherited variants in synaptic genes interact to affect synaptic function?
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  • Can inherited disorders of multiple synaptic genes be recreated in invertebrate models and in neurons derived from¬† ¬† patients?
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  • How does synaptic homeostasis interact with inherited genetic variability in synaptic proteins?
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  • How do alterations in synaptic function affect the operation of small circuits?
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  • How can an improved understanding of genetic synaptopathies be harnessed to treat paroxysmal neurological disorders?

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