Dr. Isabel Charlotte Hostettler

Dr. Isabel Charlotte Hostettler, MD, is a PhD student with a profound interest in clinical studies on brain haemorrhages. She is currently mainly working on genome-wide association studies (GWAS) in patients with different types of stroke: intracerebral haemorrhage (ICH), aneurysmal subarachnoid haemorrhage (aSAH) and ischaemic stroke (IS). She works in the research group led by Professor Henry Houlden for all genetical statistical aspects of her research projects. These cohorts originated under the leadership of Professor David Werring in collaboration with Professor Henry Houlden.

Isabel studied medicine at the University of Basel, Switzerland, graduated in 2011 and dissertated on the topic of “ABCG5-positivity in tumor buds is a poor prognostic indicator for node-negative colorectal cancer patients”. From 2011 to 2014 she worked at the University Hospital of Zurich as a neurosurgical trainee until she moved to the UK, London in 2014 to start a PhD in the Stroke Research Centre. During her PhD she has developed a strong interest in clinical and genetic aspects of intracerebral and subarachnoid haemorrhage.

Isabel is currently analysing GWAS data obtained in two large well-phenotyped cohort studies (GOSH – Genetics of Subarachnoid Haemorrhage; and CROMIS – clinical relevance of microbleeds in stroke) led by  Professor David Werring in collaboration with Professor Henry Houlden at the Institute of Neurology, University College London. She is currently developing her skills and working on the GWAS of the CROMIS-2 intracerebral haemorrhage cohort which will be followed by the GWAS of GOSH and the CROMIS-2 ischaemic stroke (atrial fibrillation) cohorts. She has developed different lab and statistical techniques to identify genetic markers. The aim of these studies is to improve the genetic characterisation and put them into context with clinical and imaging data in these well-phenotyped cohorts.

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