Francesca Magrinelli - 1310

Dr Francesca Magrinelli

Dr Francesca Magrinelli graduated in Medicine and Surgery at the University of Verona, Italy in 2011. During her general neurology training at the University Hospital of Verona, she was accepted for a 4-month observership at the National Hospital for Neurology and Neurosurgery, London, UK under the supervision of Professor Kailash Bhatia. Since then, her main clinical and research interests have become movement disorders and neurogenetics of movement disorders and neurodegeneration.

Dr Magrinelli started a PhD degree in Neurosciences at the University of Verona, Italy in 2017 (supervisor Professor Michele Tinazzi) and specialized in Neurology in 2018. In 2019, she moved to the UK to deepen her clinical expertise in movement disorders and practical laboratory and analytical skills in neurogenetics. Her PhD program has mainly been focused on the genetic bases of isolated and combined dystonia, including dystonia-parkinsonism, explored through whole genome sequencing.

Dr Magrinelli is currently Research Associate to Professor Kailash Bhatia and Professor Henry Houlden at the UCL Queen Square Institute of Neurology, University College London. She works as Clinical Assistant to Professor Kailash Bhatia at the National Hospital for Neurology and Neurosurgery (London), being involved in the Movement Disorder and Botulinum Toxin clinics. She is working in Professor Houlden’s neurogenetic laboratory, building up her practical laboratory skills (including DNA extraction from blood, RNA extraction from blood and skin fibroblasts, PCR, RT-PCR, RP-PCR, Sanger Sequencing, Southern blotting, Western blotting, skin biopsy processing) and analytical genetic skills (including variant filtering from SNP genotyping, whole exome sequencing, and whole genome sequencing, segregation analysis, linkage analysis, and homozygosity mapping).

Dr Magrinelli has cooperated with the Neurology and Neurodegeneration Genomics England Clinical Interpretation Partnership (GeCIP) and she is reviewing all cases of movement disorders and neurodegeneration submitted to the UK 100,000 Genomes Project at the National Hospital for Neurology and Neurosurgery, with a focus on deep phenotyping and phenotype-genotype. She is recruiting patients with familial movement disorders of unknow etiology who are followed up in Professor Bhatia’s clinics.

Dr Magrinelli has been awarded with the EAN Research Fellowship 2020 by the European Academy of Neurology for the project “Dissecting the genetic bases of isolated and combined dystonia through whole genome sequencing”.

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